We have discovered a divergent molecular and cellular mechanism regulating the activity of the Robo axon guidance receptor in the fly brain suggesting that the organizational principles of neuronal circuit wiring differ between the brain and the spinal cord. Robo receptors are crucial regulators of circuit wiring in the mammalian brain, and this discovery may be relevant in that context as well.
You can read all about it at here!
Our laboratory is moving from VIB in Leuven, Belgium to ICM (Brain & Spine Institute) in Paris, France. Throughout this year we will be slowly closing our operations in Leuven and starting up in Paris. In 2017 our move will be finished.
Our team has recently discovered a previously unknown mechanism that is highly conserved between species and which regulates neurogenesis through precise temporal control of the activity of a family of proteins essential for brain development: the proneural proteins. This mechanism, a simple reversible chemical modification, is critical for the production of a sufficient number of neurons, their differentiation and the development of the nervous system.